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cydD [2019-04-24 13:15:10]
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cydD [2019-04-24 13:15:10]

ABC transporter required for expression of cytochrome bd (ATP-binding protein)
locus
BSU38730
pI
6.22
mw
64.34 kDa
protein length
575 aa Sequence Blast
gene length
1728 bp Sequence Blast
function
required for expression of cytochrome bd
product
ABC transporter (ATP-binding protein)
essential
no
synonyms
yxkN
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.3|Regulatory ABC transporters]
  • [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.2|Respiration] → [category|SW 2.1.2.1|Terminal oxidases]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    3,973,364 3,975,091

    The protein

    [SW|Domains]

  • has both a membrane-spanning and an ATP-binding domain [Pubmed|10092453]

    • Structure

  • [PDB|2HYD] (from Staphylococcus aureus, 28% identity) [pubmed|16943773]

    • [SW|Localization]

  • cell membrane [Pubmed|10092453]

    • Expression and Regulation

    Operons

    genes
    [gene|C0459C0D45E31561D281E016D86CD80DCAF13357|cydA]-[gene|E66EAB3C172ED8D1D26C675A7338B8153FB66987|cydB]-[gene|A65576E0261F1950A0DAD72B2432D97AB3EB2AA5|cydC]-[gene|244BF9E397FDB0691FFAA8C9D419B0AE417CACE1|cydD]
    description
    [Pubmed|16207915]

    sigma factors

  • [protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|SigF]: sigma factor, [PubMed|16497325], in [regulon|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|SigF regulon]

    • regulatory mechanism

  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]
  • [protein|B5EF521437323EF43F08E5EFDB5C798616CA499A|Rex]: repression, [Pubmed|15231791], in [regulon|B5EF521437323EF43F08E5EFDB5C798616CA499A|Rex regulon]
  • [protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD]: activation, [Pubmed|17322317], in [regulon|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD regulon]

    • regulation

  • expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|17322317]
    • view in new tab

    genes
    [gene|244BF9E397FDB0691FFAA8C9D419B0AE417CACE1|cydD]
    description
    [pubmed|16497325]

    regulation

  • expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|17322317]
    • view in new tab

    Biological materials

    Mutant

  • MGNA-B748 (cydD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1747 NBRP B. subtilis, Japan]
  • BKE38730 ([gene|244BF9E397FDB0691FFAA8C9D419B0AE417CACE1|cydD]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE38730 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGGCAAAATCCATTCTTCTT, downstream forward: _UP4_TAAAAGACAGCCCTAAAAGG
  • BKK38730 ([gene|244BF9E397FDB0691FFAA8C9D419B0AE417CACE1|cydD]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK38730 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGGCAAAATCCATTCTTCTT, downstream forward: _UP4_TAAAAGACAGCCCTAAAAGG

    • References

  • 15231791,16207915,17322317,10092453,16497325,9852001,15231791,17322317,24958725,16943773